2017 Colorado Protein Stability Conference

Breckenridge, Colorado
Monday, July 17, 2017

Conference Overview

Pre-conference Workshop on Biophysical Characterization and Particle Analysis, Monday, July 17
Sponsored by Malvern
Complimentary to conference registrants 

Lunch 12 pm
Workshop 1pm

Malvern Instruments is proud to sponsor a complimentary Workshop on Biophysical Characterization and Particle Analysis. During this workshop, you will have the opportunity to interact with technical experts and advanced users. There will be time to troubleshoot issues, learn how to better understand your data (feel free to bring it along!), and to network with others using these techniques for stability profiling and characterization of particles.  There will be scientists with a wide range of interests in attendance on the day, and we welcome everyone, from novices to expert users

Opening reception. There will be an opening reception with buffer dinner and beverages at 7 pm on Monday, July 17.

Plenary lectures. The topics for the plenary lectures will include:

  • Protein Folding, Dynamics and Thermodynamic Stability
  • Amyloidosis and Protein Aggregation
  • Stability, Formulation, Analysis and Processing of Therapeutic Proteins

Poster session. There will be a poster session for contributed papers on the morning of Wednesday, July 19. This session will allow for further discussions of the critical issues.

Closing reception. There will be a closing reception with buffet dinner and beverages at 6:00 pm on Thursday, July 20.

Abstract Submission for Poster Session

Abstracts should be prepared on a single page with one-inch margins. Abstracts will be reproduced as received for the proceedings booklet of the Conference. Abstracts should be submitted no later than June 15th, 2017 to john.carpenter@ucdenver.edu.

Student Poster Competition

The Center for Pharmaceutical Biotechnology and the Conference Sponsors are proud to sponsor this competition to promote excellence in student research. The student presenting the poster judged to be the best will receive The Timasheff Award. The Award is established in honor of our mentor and friend, Prof. Serge N. Timasheff, whose creative, rigorous research has provided us with so many critically important ways to address and understand fundamental issues in biology and biophysical chemistry. The cash prizes are: $1000 for the winner, $500 for first runner-up and $250 for second runner-up.

Students should send their abstracts to John Carpenter by email and indicate in the email message that they wish to enter the competition.


The registration fee covers conference registration, abstract booklet, breakfast and lunch each day, morning and afternoon coffee breaks, and opening and closing receptions with buffet dinner and beverages.

Registration Fees (before May 15)
Registration Fee $975
Government Rate $575
Student/Postdoc Rate $475
Late Registration Fees (after May 15)
Late Registration Fee $1375
Late Government Rate $750
Late Student Postdoc Rate $650

Cancellation Policy

Only requests for cancellation received prior to June 15th, 2017 will receive a refund, minus a $100 processing fee. If cancellation is not received by June 15th, 2017, the registration fee will be forfeited.

Conference Schedule

Monday, July 17
    Pre-Conference Workshop

12:00 pm Lunch for workshop participants

Workshop on Biophysical Characterization and Particle Analysis                 
Sponsored by Malvern           

1:00        Merry Christie, US FDA
Roles of nano- and microparticles in adverse immunogenicity

1:30         Amber Fradkin, KBI Biopharma
        Critical methods for counting and sizing subvisible particles

2:00          Kevin Dahl, KBI Biopharma
         Automated Raman microscopy for characterization and 
 identification of particles

2:30         John Gabrielson, Elion Labs
      Biophysical characterization for regulatory filings and 
comparability studies

3:00         Kelly Arthur, Elion Labs
Differential scanning calorimetry for therapeutic protein product       characterization and comparability studies

3:30          Coffee break

4:00          Panel discussion

4:40          Break out session one

5:20          Break out session two 

Break out session topics

1.     Differential scanning calorimetry 
2.     Light scattering
3.     Automated Raman microscopy
4.     Resonant mass measurement
5.     Nanoparticle tracking analysis
6.     Taylor dispersion analysis

    7:00 pm  
Opening Reception
Tuesday, July 18 

      7:30 am Breakfast

8:25 John Carpenter, Univ. of Colorado Welcoming Comments

 Protein Folding, Dynamics and Thermodynamic Stability

8:30      Ken Dill, Stony Brook Univ. 
      Proteins under stress in folding and aggregation

9:05      Eugene Shakhnovich, Harvard Univ.
     Protein stability in celular context: Physics meets evolution

9:40      Yang Zhang, Univ. of Michigan
     Protein folding and protein design

10:15    Coffee Break 

10:45    Valerie Daggett, Univ. of Washington
     Dynameomics: From simulation of all protein folds to 
     the design of amyloid inhibitors and diagnostics

11:20     Lars Konermann, Univ. of Western Ontario
      Studying protein dynamics by hydrogen exchange mass
              spectrometry: From enzymes to molecular motors

11:55     Annette Sievers, Pfizer
      Early discovery biophysical analysis to enable selection of
                           better therapeutic molecules

12:30pm Lunch

1:30         Jeremy Schmit, Kansas State Univ. 
        Salt entropy contributions to protein solubility and the Hofmeister

2:05         Scott Banta, Columbia Univ. 
        Characterizing the conformationally dynamic Beta Roll
                 peptide domain and engineering it to participate in 
                 useful bimolecular interactions

2:40          Chris Roberts, Univ. of Delaware
         Combining molecular models and scattering for antibody
                  interactions from low to high protein concentration
3:15           Coffee Break

Amyloidosis and Protein Aggregation

3:45            Yolanda Hedberg, KTH Royal Institute of Technology
            Metal induced protein agglomeration

4:20             Steve Bourgault, Univ. of Quebec
            Chemical approaches to probe and manipulate
            amyloid assembly

4:55             Dan Raleigh, SUNY Stony Brook
             Protein misfolding and Type-2 diabetes: From basic
    biophysics to beta-cell death

Wednesday, July 19

8:00 am        Breakfast

9:00              Poster Session

9 - 11 am    Even numbered posters presented

                             11 - 1pm     Odd numbered posters presented

1:00 pm        Lunch

Thursday, July 20

7:30 am         Breakfast

Formulation, Analysis and Processing of Therapeutic Proteins

8:30               Rukman DeSilva, US FDA
      Scientific and regulatory considerations in evaluating
                      aggregates in biotherapeutic products

9:05               Amber Fradkin, KBI
                      Multiple methods for characterization of particles

9:40               Christine Probst, Amnis -- EMD Millipore
      Characterization of sub-visible particles with multi-spectral
      imaging flow cytometry

10:15             Coffee  Break

10:45             Daniela Verthelyi, US FDA
      Impurities and identity: what can the transcriptome
      tell us?

11:20             Bruce Kerwin, Just Biotherapeutics
      Reducing the costs of biologics combining modeling
              and high throughput screening of monoclonal antibodies

11:55              Karyn O'Neil, JNJ
       Exploiting the biophysical properties of Centyrins for
targeted delivery

12:30pm        Lunch

1:30               Gerhard Winter, Ludwig-Maximilians Univ. 
      New studies of protein drugs in plastic syringes

2:05               Wolfgang Friess, Ludwig-Maximilians Univ.
      Minimizing silicone levels in biopharmaceuticals

2:40               Robert Latour, Clemson Univ.
      Characterizing of adsorbed protein orientation and
and their effects on bioactivity

3:15               Coffee Break

3:45               Satish Singh, Lonza
              Understanding surfactants? -- do or do not, there is no try?

4:20               David Volkin, Univ. of Kansas
      Probing the interface of protein stability analysis, formulation
              development and biosimilarity assessments

4:55               Mike Pikal, Univ. of Connecticut
      Impact of natural variations in freeze drying on process design
       and protein stability

6:00               Closing Reception


Contact Information

Payment Instructions

  • We accept the following Credit Cards          for this Workshop

    Visa - Mastercard - Discover - American Express
© 2018
Quick, easy and affordable online event registration and event management software for all event sizes.