New drug candidates for all therapeutic targets must have drug-like properties (ability to be administered in vivo for therapeutic benefit) and must not cause harm (be safe). To assess the drug-like properties of a new candidate, medicinal chemists use Pharmacokinetics, Pharmacodynamics and Safety Pharmacology. In addition, Pharmacodynamics tools are used to assess and predict the primary activity for drug targets in all systems including the therapeutic one(s). This course will provide attendees with a fundamental and in-depth understanding of the critical concepts governing pharmacokinetics (ADME studies), primary pharmacology, and safety pharmacology as related to drug candidates. It will highlight key terminology, mechanisms, and innovative assessment and predictive strategies used in current drug discovery processes.