The purpose of this two-day train-the-trainers workshop is to help new or inexperienced Responsible Conduct of Research (RCR) instructors to develop and implement best practices in RCR instruction. The course presenters are experienced RCR instructors and researchers who will present distinct topics, lead active discussions and exercises, and identify useful resources (case studies, short writing assignments, etc.) for a foundational understanding of RCR and the tools needed for successful RCR instruction. Particular focus will be on active learning approaches most effective for adult learners. Four topic sessions (data; misconduct; collaboration; and publication and authorship) will demonstrate effective teaching methods and illustrate positive and negative practices in the conduct of research. In addition, three sessions (pedagogy, assessment, and RCR program management) will introduce structural, practical, tactical, and strategic aspects of RCR instruction.