This course presents the fundamentals of pharmacokinetics and pharmacodynamics as they apply to the chemical structure of drugs. There will be specific discussion of the role of medicinal chemistry in the drug discovery process; how chemical structure affects the absorption, distribution, metabolism and excretion (ADME properties) of drugs; and drug affinity and efficacy (Pharmacodynamics). In addition, students will learn the essentials of interpreting pharmacokinetic data from animal studies for prediction of first dose in humans and therapeutic use of drugs. By the end of this course, students should be able to understand the role of the medicinal chemist in the process of drug discovery and development. This course is centered on gaining an understanding of in vitro PK assay data (Caco-2, MDCK, PAMPA, microsomes, hepatocytes etc) to predict in vivo PK and optimize drug ADME properties. In vivo data interpretation (scaling from animal to humans, allometric plots) will be discussed with specific examples of the role of pharmacokinetics in drug development.
This course will meet for six online sessions at 12:30 PM - 1:45 PM on the following dates: